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GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.

ABSTRACT: Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

SUBMITTER: Chen MM 

PROVIDER: S-EPMC5868213 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.

Chen Maxine M MM   O'Mara Tracy A TA   Thompson Deborah J DJ   Painter Jodie N JN   Attia John J   Black Amanda A   Brinton Louise L   Chanock Stephen S   Chen Chu C   Cheng Timothy Ht TH   Cook Linda S LS   Crous-Bou Marta M   Doherty Jennifer J   Friedenreich Christine M CM   Garcia-Closas Montserrat M   Gaudet Mia M MM   Gorman Maggie M   Haiman Christopher C   Hankinson Susan E SE   Hartge Patricia P   Henderson Brian E BE   Hodgson Shirley S   Holliday Elizabeth G EG   Horn-Ross Pamela L PL   Hunter David J DJ   Le Marchand Loic L   Liang Xiaolin X   Lissowska Jolanta J   Long Jirong J   Lu Lingeng L   Magliocco Anthony M AM   Martin Lynn L   McEvoy Mark M   Olson Sara H SH   Orlow Irene I   Pooler Loreall L   Prescott Jennifer J   Rastogi Radhai R   Rebbeck Timothy R TR   Risch Harvey H   Sacerdote Carlotta C   Schumacher Frederick F   Wendy Setiawan Veronica V   Scott Rodney J RJ   Sheng Xin X   Shu Xiao-Ou XO   Turman Constance C   Van Den Berg David D   Wang Zhaoming Z   Weiss Noel S NS   Wentzensen Nicholas N   Xia Lucy L   Xiang Yong-Bing YB   Yang Hannah P HP   Yu Herbert H   Zheng Wei W   Pharoah Paul D P PD   Dunning Alison M AM   Tomlinson Ian I   Easton Douglas F DF   Kraft Peter P   Spurdle Amanda B AB   De Vivo Immaculata I  

Human molecular genetics 20160323 12

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 <sup>-</sup><sup>8</sup>) at 6p22.3 (rs1740828; P = 2.29 × 10 <sup>-</sup><sup>  ...[more]

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