Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.

ABSTRACT:

Objective

Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our aim was to evaluate the composition of the gastric microbiota in chronic gastritis and in gastric carcinoma.

Design

The gastric microbiota was retrospectively investigated in 54 patients with gastric carcinoma and 81 patients with chronic gastritis by 16S rRNA gene profiling, using next-generation sequencing. Differences in microbial composition of the two patient groups were assessed using linear discriminant analysis effect size. Associations bet

SUBMITTER: Ferreira RM 

PROVIDER: S-EPMC5868293 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature