Ontology highlight
ABSTRACT:
SUBMITTER: McGann PT
PROVIDER: S-EPMC5868345 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
McGann Patrick T PT Ware Russell E RE
Expert opinion on drug safety 20150914 11
<h4>Introduction</h4>Sickle cell anemia (SCA) is a severe, inherited hemoglobin disorder affecting 100,000 persons in the US and millions worldwide. Hydroxyurea, a once daily oral medication, has emerged as the primary disease-modifying therapy for SCA. The accumulated body of evidence over 30 years demonstrates that hydroxyurea is a safe and effective therapy for SCA, but hydroxyurea remains underutilized for a variety of reasons.<h4>Areas covered</h4>In this review, we summarize the available ...[more]