Ontology highlight
ABSTRACT:
SUBMITTER: Lungova V
PROVIDER: S-EPMC5869008 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lungova Vlasta V Verheyden Jamie M JM Sun Xin X Thibeault Susan L SL
Development (Cambridge, England) 20180216 4
Congenital laryngeal webs result from failure of vocal fold separation during development <i>in utero</i> Infants present with life-threatening respiratory problems at birth, and extensive lifelong difficulties in breathing and voicing. The molecular mechanisms that instruct vocal fold formation are rarely studied. Here, we show, for the first time, that conditional inactivation of the gene encoding β-catenin in the primitive laryngopharyngeal epithelium leads to failure in separation of the voc ...[more]