Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction.
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ABSTRACT:
SUBMITTER: Nguyen CT
PROVIDER: S-EPMC5869026 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction.
Nguyen Christopher T CT Dawkins James J Bi Xiaoming X Marbán Eduardo E Li Debiao D
JACC. Basic to translational science 20180201 1
The object of the study was to reveal the fiber microstructural response with diffusion tensor cardiac magnetic resonance after intramyocardial exosomes secreted by cardiosphere-derived cells (CDC<sub>EXO</sub>) in chronic porcine myocardial infarction. Porcine with myocardial infarction underwent intramyocardial delivery of human CDC<sub>EXO</sub> and placebo in a randomized placebo-controlled study. Four weeks after injection, viability improved in the CDC<sub>EXO</sub> group, whereas myocardi ...[more]
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