Ontology highlight
ABSTRACT:
SUBMITTER: Wong G
PROVIDER: S-EPMC5869240 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Wong Gary G Cao Wen-Guang WG He Shi-Hua SH Zhang Zi-Rui ZR Zhu Wen-Jun WJ Moffat Estella E Ebihara Hideki H Embury-Hyatt Carissa C Qiu Xiang-Guo XG
Zoological research 20180101 1
The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the development and characterization of a MARV/Ang variant that can cause lethal disease in mice (MARV/Ang-MA), with the aim of using this tool to screen for promising prophylactic and therapeutic candidates. An intermediate animal model is needed to confirm any findi ...[more]