Unknown

Dataset Information

0

Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam.


ABSTRACT: Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.

SUBMITTER: Van Nguyen D 

PROVIDER: S-EPMC5869495 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7165641 | biostudies-literature
| S-EPMC9170927 | biostudies-literature
| S-EPMC10534609 | biostudies-literature
| S-EPMC4526568 | biostudies-literature
| S-EPMC6199981 | biostudies-literature
| S-EPMC3657805 | biostudies-literature
| S-EPMC4676424 | biostudies-literature
| S-EPMC10131556 | biostudies-literature
| S-EPMC6408376 | biostudies-literature
| S-EPMC6598888 | biostudies-literature