Ontology highlight
ABSTRACT:
SUBMITTER: Mendes A
PROVIDER: S-EPMC5869531 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Mendes Adriano A Kuhn Richard J RJ
Viruses 20180320 3
Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve. In this review, we will summarize what is known about the alphavirus capsid protein, the packaging signal, and their roles in the mechanism of packaging and assembly. We will review the disco ...[more]