Ontology highlight
ABSTRACT:
SUBMITTER: Asaumi R
PROVIDER: S-EPMC5869557 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Asaumi Ryuta R Toshimoto Kota K Tobe Yoshifusa Y Hashizume Kenta K Nunoya Ken-Ichi KI Imawaka Haruo H Lee Wooin W Sugiyama Yuichi Y
CPT: pharmacometrics & systems pharmacology 20180205 3
This study aimed to construct a physiologically based pharmacokinetic (PBPK) model of rifampicin that can accurately and quantitatively predict complex drug-drug interactions (DDIs) involving its saturable hepatic uptake and auto-induction. Using in silico and in vitro parameters, and reported clinical pharmacokinetic data, rifampicin PBPK model was built and relevant parameters for saturable hepatic uptake and UDP-glucuronosyltransferase (UGT) auto-induction were optimized by fitting. The param ...[more]