Ontology highlight
ABSTRACT:
SUBMITTER: Cytlak U
PROVIDER: S-EPMC5869589 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cytlak Urszula U Resteu Anastasia A Bogaert Delfien D Kuehn Hye Sun HS Altmann Thomas T Gennery Andrew A Jackson Graham G Kumanovics Attila A Voelkerding Karl V KV Prader Seraina S Dullaers Melissa M Reichenbach Janine J Hill Harry H Haerynck Filomeen F Rosenzweig Sergio D SD Collin Matthew M Bigley Venetia V
Nature communications 20180327 1
Ikaros family zinc finger 1 (IKZF1) is a haematopoietic transcription factor required for mammalian B-cell development. IKZF1 deficiency also reduces plasmacytoid dendritic cell (pDC) numbers in mice, but its effects on human DC development are unknown. Here we show that heterozygous mutation of IKZF1 in human decreases pDC numbers and expands conventional DC1 (cDC1). Lenalidomide, a drug that induces proteosomal degradation of IKZF1, also decreases pDC numbers in vivo, and reduces the ratio of ...[more]