Ontology highlight
ABSTRACT:
SUBMITTER: Wiemann M
PROVIDER: S-EPMC5869651 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Wiemann Martin M Sauer Ursula G UG Vennemann Antje A Bäcker Sandra S Keller Johannes-Georg JG Ma-Hock Lan L Wohlleben Wendel W Landsiedel Robert R
Nanomaterials (Basel, Switzerland) 20180313 3
In vitro prediction of inflammatory lung effects of well-dispersed nanomaterials is challenging. Here, the in vitro effects of four colloidal amorphous SiO₂ nanomaterials that differed only by their primary particle size (9, 15, 30, and 55 nm) were analyzed using the rat NR8383 alveolar macrophage (AM) assay. Data were compared to effects of single doses of 15 nm and 55 nm SiO₂ intratracheally instilled in rat lungs. In vitro, all four elicited the release of concentration-dependent lactate dehy ...[more]