Ontology highlight
ABSTRACT:
SUBMITTER: Koudijs KKM
PROVIDER: S-EPMC5869697 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Koudijs Karel K M KKM Terwisscha van Scheltinga Anton G T AGT Böhringer Stefan S Schimmel Kirsten J M KJM Guchelaar Henk-Jan HJ
Scientific reports 20180327 1
Reversal of cancer gene expression is predictive of therapeutic potential and can be used to find new indications for existing drugs (drug repositioning). Gene expression reversal potential is currently calculated, in almost all studies, by pre-aggregating all tumour samples into a single group signature or a limited number of molecular subtype signatures. Here, we investigate whether drug repositioning based on individual tumour sample gene expression signatures outperforms the use of tumour gr ...[more]