Dopamine-dependent social information processing in non-human primates.

ABSTRACT: RATIONALE:Dopamine (DA) is a neurotransmitter whose roles have been suggested in various aspects of brain functions. Recent studies in rodents have reported its roles in social function. However, how DA is involved in social information processing in primates has largely remained unclear. OBJECTIVES:We investigated prefrontal cortical (PFC) activities associated with social vs. nonsocial visual stimulus processing. METHODS:Near-infrared spectroscopy (NIRS) was applied to Japanese macaques, along with pharmacological manipulations of DA transmission, while they were gazing at social and nonsocial visual stimuli. RESULTS:Oxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin changes as well as functional connectivity based on such Hb changes within the PFC network which were distinct bet

SUBMITTER: Lee YA 

PROVIDER: S-EPMC5869898 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature