Ontology highlight
ABSTRACT:
SUBMITTER: Marteil G
PROVIDER: S-EPMC5871873 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Marteil Gaëlle G Guerrero Adan A Vieira André F AF de Almeida Bernardo P BP Machado Pedro P Mendonça Susana S Mesquita Marta M Villarreal Beth B Fonseca Irina I Francia Maria E ME Dores Katharina K Martins Nuno P NP Jana Swadhin C SC Tranfield Erin M EM Barbosa-Morais Nuno L NL Paredes Joana J Pellman David D Godinho Susana A SA Bettencourt-Dias Mónica M
Nature communications 20180328 1
Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive breas ...[more]