Ontology highlight
ABSTRACT:
SUBMITTER: Ng ASL
PROVIDER: S-EPMC5871891 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Ng Adeline S L ASL Ng Ebonne Y L EYL Tan Yi Jayne YJ Prakash Kumar M KM Au Wing Lok WL Tan Louis C S LCS Tan Eng-King EK
Scientific reports 20180328 1
Co-existence of Parkinson's disease (PD) and essential tremor (ET) may reflect overlapping pathophysiology underlying both conditions. Furthermore, PD patients with leucine-rich repeat kinase-2 (LRRK2) mutations may present with ET-like features, suggesting the possibility of common genetic underpinnings. Two common LRRK2 variants, R1398H and N551K, have been shown to be protective in multiple PD cohorts. We hypothesized that R1398H and N551K may show a similar effect in ET. In a case-control st ...[more]