The endocannabinoid system in guarding against fear, anxiety and stress.
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ABSTRACT:
SUBMITTER: Lutz B
PROVIDER: S-EPMC5871913 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
The endocannabinoid system in guarding against fear, anxiety and stress.
Lutz Beat B Marsicano Giovanni G Maldonado Rafael R Hillard Cecilia J CJ
Nature reviews. Neuroscience 20151201 12
The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB signalling seems to determine the value of fear-evoking stimuli and to tune appropriate behavioural responses, which are essential for the organism's long-term viability, homeostasis and stress resil ...[more]
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