Ontology highlight
ABSTRACT:
SUBMITTER: Tervo DG
PROVIDER: S-EPMC5872824 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Tervo D Gowanlock R DG Hwang Bum-Yeol BY Viswanathan Sarada S Gaj Thomas T Lavzin Maria M Ritola Kimberly D KD Lindo Sarah S Michael Susan S Kuleshova Elena E Ojala David D Huang Cheng-Chiu CC Gerfen Charles R CR Schiller Jackie J Dudman Joshua T JT Hantman Adam W AW Looger Loren L LL Schaffer David V DV Karpova Alla Y AY
Neuron 20161006 2
Efficient retrograde access to projection neurons for the delivery of sensors and effectors constitutes an important and enabling capability for neural circuit dissection. Such an approach would also be useful for gene therapy, including the treatment of neurodegenerative disorders characterized by pathological spread through functionally connected and highly distributed networks. Viral vectors, in particular, are powerful gene delivery vehicles for the nervous system, but all available tools su ...[more]