Method for identification of condition-associated public antigen receptor sequences.
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ABSTRACT:
SUBMITTER: Pogorelyy MV
PROVIDER: S-EPMC5873893 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Method for identification of condition-associated public antigen receptor sequences.
Pogorelyy Mikhail V MV Minervina Anastasia A AA Chudakov Dmitriy M DM Mamedov Ilgar Z IZ Lebedev Yuri B YB Mora Thierry T Walczak Aleksandra M AM
eLife 20180313
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously vali ...[more]
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