Ontology highlight
ABSTRACT:
SUBMITTER: Parker KL
PROVIDER: S-EPMC5873945 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Parker K L KL Kim Y C YC Kelley R M RM Nessler A J AJ Chen K-H KH Muller-Ewald V A VA Andreasen N C NC Narayanan N S NS
Molecular psychiatry 20170328 5
Schizophrenia involves abnormalities in the medial frontal cortex that lead to cognitive deficits. Here we investigate a novel strategy to normalize medial frontal brain activity by stimulating cerebellar projections. We used an interval timing task to study elementary cognitive processing that requires both frontal and cerebellar networks that are disrupted in patients with schizophrenia. We report three novel findings. First, patients with schizophrenia had dysfunctional delta rhythms between ...[more]