Fresh red blood cells transfusion protects against aluminum phosphide-induced metabolic acidosis and mortality in rats.

ABSTRACT: BACKGROUND:Aluminum phosphide (AlP) is used as pesticide in some countries for protection of stored grains. Human poisoning with AlP due to suicide attempt or accidental environmental exposure is associated with very high mortality partially due to development of severe metabolic acidosis. Previous studies have shown that hemoglobin has high buffering capacity and erythrocytes can potentially be used for management of metabolic acidosis. The aim of this study was to evaluate the effect of fresh packed red blood cells (RBC) transfusion on survival and cardiovascular function in AlP-poisoned rats. METHODOLOGY/PRINCIPAL FINDINGS:Rats were poisoned with AlP by gavage. Fresh packed RBC was transfused via tail vein after AlP administration. Acid-base balance, vital signs and mortality was assess

SUBMITTER: Rahimi N 

PROVIDER: S-EPMC5874013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature