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Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal.

ABSTRACT: We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance.

SUBMITTER: Isidro J

PROVIDER: S-EPMC5875251 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal.

Isidro Joana J Santos Andrea A Nunes Alexandra A Borges Vítor V Silva Catarina C Vieira Luís L Mendes Aristides L AL Serrano Mónica M Henriques Adriano O AO Gomes João Paulo JP Oleastro Mónica M

Emerging infectious diseases 20180401 4

We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had additional substitutions near the transpeptidase active sites of pbp1 and pbp3. These clones could disseminate and contribute to imipenem resistance. ...[more]

PMID: 29553322

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