Association of Early-Life Factors With Life-Course Trajectories of Resting Heart Rate: More Than 6 Decades of Follow-up.

ABSTRACT:

Importance

Higher resting heart rate (RHR) is associated with increased risk of cardiovascular and all-cause mortality. Limited attention has been paid to early-life determinants of life-course RHR.

Objective

To describe trajectories of RHR in the same individuals from age 6 to 69 years.

Design, setting, and participants

Data were from the Medical Research Council National Survey of Health and Development population-based cohort of individuals who were followed up from birth in 1946 until 2015. Analysis was conducted between September 2016 and June 2017. Multilevel models were used to estimate life-course mean RHR trajectory by sex and to investigate associations with early childhood factors. The maximal sample included participants who had at least 1 measure of RHR s

SUBMITTER: O'Hare C 

PROVIDER: S-EPMC5875352 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature