Ontology highlight
ABSTRACT:
SUBMITTER: Lucey BP
PROVIDER: S-EPMC5876097 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Lucey Brendan P BP Hicks Terry J TJ McLeland Jennifer S JS Toedebusch Cristina D CD Boyd Jill J Elbert Donald L DL Patterson Bruce W BW Baty Jack J Morris John C JC Ovod Vitaliy V Mawuenyega Kwasi G KG Bateman Randall J RJ
Annals of neurology 20180101 1
Sleep disturbances are associated with future risk of Alzheimer disease. Disrupted sleep increases soluble amyloid β, suggesting a mechanism for sleep disturbances to increase Alzheimer disease risk. We tested this response in humans using indwelling lumbar catheters to serially sample cerebrospinal fluid while participants were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. All participants were infused with <sup>13</sup> C<sub>6</sub> -leucine to measure amyloid β k ...[more]