Ontology highlight
ABSTRACT:
SUBMITTER: Wang P
PROVIDER: S-EPMC5876331 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nature communications 20180329 1
ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, using X-ray crystallography and SAXS characterization, we demonstrate that PML RING tetramerizes through highly conserved PML-specific sequences, which are required for NB assembly and PML sumoylation. C ...[more]