Ontology highlight
ABSTRACT:
SUBMITTER: Wu Y
PROVIDER: S-EPMC5876467 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wu Yupeng Y Wang Yadong Y Liu Ming M Nie Min M Wang Ying Y Deng Yexuan Y Yao Bing B Gui Tao T Li Xinyu X Ma Lingling L Guo Chan C Ma Chi C Ju Junyi J Zhao Quan Q
Oncology letters 20180221 5
Methylation of histone H4 lysine 20 (H4K20) has been associated with cancer. However, the functions of the histone methyltransferases that trigger histone H4K20 methylation in cancers, including suppressor of variegation 4-20 homolog 1 (Suv4-20h1), remain elusive. In the present study, it was demonstrated that the knockdown of the histone H4K20 methyltransferase Suv4-20h1 resulted in growth inhibition in chronic myeloid leukemia K562 cells. Disruption of Suv4-20h1 expression induced G<sub>1</sub ...[more]