Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell ME
PROVIDER: S-EPMC5876725 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
O'Donnell Michael E ME Li Huilin H
Nature structural & molecular biology 20180129 2
DNA replication requires separation of genomic duplex DNA strands, an operation that is performed by a hexameric ring-shaped helicase in all domains of life. The structures and chemomechanical actions of these fascinating machines are coming into sharper focus. Although there is no evolutionary relationship between the hexameric helicases of bacteria and those of archaea and eukaryotes, they share many fundamental features. Here we review recent studies of these two groups of hexameric helicases ...[more]