Ontology highlight
ABSTRACT:
SUBMITTER: Lanzafame M
PROVIDER: S-EPMC5877543 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lanzafame Manuela M Bianco Gaia G Terracciano Luigi M LM Ng Charlotte K Y CKY Piscuoglio Salvatore S
International journal of molecular sciences 20180228 3
Whole-transcriptome analyses have revealed that a large proportion of the human genome is transcribed in non-protein-coding transcripts, designated as long non-coding RNAs (lncRNAs). Rather than being "transcriptional noise", increasing evidence indicates that lncRNAs are key players in the regulation of many biological processes, including transcription, post-translational modification and inhibition and chromatin remodeling. Indeed, lncRNAs are widely dysregulated in human cancers, including h ...[more]