Ontology highlight
ABSTRACT:
SUBMITTER: Le Nail LR
PROVIDER: S-EPMC5877568 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Le Nail Louis-Romée LR Brennan Meadhbh M Rosset Philippe P Deschaseaux Frédéric F Piloquet Philippe P Pichon Olivier O Le Caignec Cédric C Crenn Vincent V Layrolle Pierre P Hérault Olivier O De Pinieux Gonzague G Trichet Valérie V
International journal of molecular sciences 20180301 3
Osteosarcoma (OS) is suspected to originate from dysfunctional mesenchymal stromal/stem cells (MSC). We sought to identify OS-derived cells (OSDC) with potential cancer stem cell (CSC) properties by comparing OSDC to MSC derived from bone marrow of patients. This study included in vitro characterization with sphere forming assays, differentiation assays, cytogenetic analysis, and in vivo investigations of their tumorigenicity and tumor supportive capacities. Primary cell lines were isolated from ...[more]