The Role of mTOR in Neuroendocrine Tumors: Future Cornerstone of a Winning Strategy?
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SUBMITTER: Lamberti G
PROVIDER: S-EPMC5877608 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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The Role of mTOR in Neuroendocrine Tumors: Future Cornerstone of a Winning Strategy?
Lamberti Giuseppe G Brighi Nicole N Maggio Ilaria I Manuzzi Lisa L Peterle Chiara C Ambrosini Valentina V Ricci Claudio C Casadei Riccardo R Campana Davide D
International journal of molecular sciences 20180306 3
The mechanistic target of rapamycin (mTOR) is part of the phosphoinositide-3-kinase (PI3K)/protein kinase B (AkT)/mTOR pathway and owes its name to the inhibitory effect of rapamycin. The mTOR has a central converging role for many cell functions, serving as a sensor for extracellular signals from energy status and nutrients availability, growth factors, oxygen and stress. Thus, it also modulates switch to anabolic processes (protein and lipid synthesis) and autophagy, in order to regulate cell ...[more]
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