Ontology highlight
ABSTRACT:
SUBMITTER: Sarin N
PROVIDER: S-EPMC5877628 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sarin Navin N Engel Florian F Rothweiler Florian F Cinatl Jindrich J Michaelis Martin M Frötschl Roland R Fröhlich Holger H Kalayda Ganna V GV
International journal of molecular sciences 20180307 3
The major obstacle in the clinical use of the antitumor drug cisplatin is inherent and acquired resistance. Typically, cisplatin resistance is not restricted to a single mechanism demanding for a systems pharmacology approach to understand a whole cell's reaction to the drug. In this study, the cellular transcriptome of untreated and cisplatin-treated A549 non-small cell lung cancer cells and their cisplatin-resistant sub-line A549<sup>r</sup>CDDP<sup>2000</sup> was screened with a whole genome ...[more]