Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC5877634 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhang Feng F Chen Kun K Tao Hu H Kang Tingting T Xiong Qi Q Zeng Qianhui Q Liu Yang Y Jiang Siwen S Chen Mingxin M
International journal of molecular sciences 20180308 3
miR-25, a member of the miR-106b-25 cluster, has been reported as playing an important role in many biological processes by numerous studies, while the role of miR-25 in metabolism and its transcriptional regulation mechanism remain unclear. In this study, gain-of-function and loss-of-function assays demonstrated that miR-25-3p positively regulated the metabolism of C2C12 cells by attenuating phosphoinositide 3-kinase (<i>PI3K</i>) gene expression and triglyceride (TG) content, and enhancing the ...[more]