Quantification of thrombus formation in malapposed coronary stents deployed in vitro through imaging analysis.

ABSTRACT: Stent thrombosis is a major complication of coronary stent and scaffold intervention. While often unanticipated and lethal, its incidence is low making mechanistic examination difficult through clinical investigation alone. Thus, throughout the technological advancement of these devices, experimental models have been indispensable in furthering our understanding of device safety and efficacy. As we refine model systems to gain deeper insight into adverse events, it is equally important that we continue to refine our measurement methods. We used digital signal processing in an established flow loop model to investigate local flow effects due to geometric stent features and ultimately its relationship to thrombus formation. A new metric of clot distribution on each microCT slice termed norma

SUBMITTER: Brown J 

PROVIDER: S-EPMC5878124 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature