Ontology highlight
ABSTRACT:
SUBMITTER: Haggard DE
PROVIDER: S-EPMC5878140 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Haggard Derik E DE Noyes Pamela D PD Waters Katrina M KM Tanguay Robert L RL
Reproductive toxicology (Elmsford, N.Y.) 20180216
There continues to be a need to develop in vivo high-throughput screening (HTS) and computational methods to screen chemicals for interaction with the estrogen, androgen, and thyroid pathways and as complements to in vitro HTS assays. This study explored the utility of an embryonic zebrafish HTS approach to identify and classify endocrine bioactivity using phenotypically-anchored transcriptome profiling. Transcriptome analysis was conducted on zebrafish embryos exposed to 25 estrogen-, androgen- ...[more]