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Biomimetic temporal self-assembly via fuel-driven controlled supramolecular polymerization.


ABSTRACT: Temporal control of supramolecular assemblies to modulate the structural and transient characteristics of synthetic nanostructures is an active field of research within supramolecular chemistry. Molecular designs to attain temporal control have often taken inspiration from biological assemblies. One such assembly in Nature which has been studied extensively, for its well-defined structure and programmable self-assembly, is the ATP-driven seeded self-assembly of actin. Here we show, in a synthetic manifestation of actin self-assembly, an ATP-selective and ATP-fuelled, controlled supramolecular polymerization of a phosphate receptor functionalised monomer. It undergoes fuel-driven nucleation and seeded growth that provide length control and narrow dispersity of the resultant assemblies. Furthermore, coupling via ATP-hydrolysing enzymes yielded its transient characteristics. These results will usher investigations into synthetic analogues of important biological self-assembly motifs and will prove to be a significant advancement toward biomimetic temporally programmed materials.

SUBMITTER: Mishra A 

PROVIDER: S-EPMC5878180 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Biomimetic temporal self-assembly via fuel-driven controlled supramolecular polymerization.

Mishra Ananya A   Korlepara Divya B DB   Kumar Mohit M   Jain Ankit A   Jonnalagadda Narendra N   Bejagam Karteek K KK   Balasubramanian Sundaram S   George Subi J SJ  

Nature communications 20180330 1


Temporal control of supramolecular assemblies to modulate the structural and transient characteristics of synthetic nanostructures is an active field of research within supramolecular chemistry. Molecular designs to attain temporal control have often taken inspiration from biological assemblies. One such assembly in Nature which has been studied extensively, for its well-defined structure and programmable self-assembly, is the ATP-driven seeded self-assembly of actin. Here we show, in a syntheti  ...[more]

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