Ontology highlight
ABSTRACT:
SUBMITTER: Perakakis N
PROVIDER: S-EPMC5878942 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Perakakis Nikolaos N Triantafyllou Georgios A GA Fernández-Real José Manuel JM Huh Joo Young JY Park Kyung Hee KH Seufert Jochen J Mantzoros Christos S CS
Nature reviews. Endocrinology 20170217 6
Irisin is a myokine that leads to increased energy expenditure by stimulating the 'browning' of white adipose tissue. In the first description of this hormone, increased levels of circulating irisin, which is cleaved from its precursor fibronectin type III domain-containing protein 5, were associated with improved glucose homeostasis by reducing insulin resistance. Consequently, several studies attempted to characterize the role of irisin in glucose regulation, but contradictory results have bee ...[more]