Ontology highlight
ABSTRACT:
SUBMITTER: Agalou A
PROVIDER: S-EPMC5879087 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Agalou Adamantia A Thrapsianiotis Michael M Angelis Apostolis A Papakyriakou Athanasios A Skaltsounis Alexios-Leandros AL Aligiannis Nektarios N Beis Dimitris D
Frontiers in pharmacology 20180326
Zebrafish has emerged as a powerful model organism for high throughput drug screening. Several morphological criteria, transgenic lines and <i>in situ</i> expression screens have been developed to identify novel bioactive compounds and their mechanism of action. Here, we used the inhibition of melanogenesis during early zebrafish embryo development to identify natural compounds that block melanogenesis. We identified an extract from the Greek hawthorn <i>Crataegus pycnoloba</i> as a potent inhib ...[more]