Ontology highlight
ABSTRACT:
SUBMITTER: Yu G
PROVIDER: S-EPMC5879628 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Yu Guozhi G Baeder Desiree Y DY Regoes Roland R RR Rolff Jens J
Proceedings. Biological sciences 20180301 1874
Antibiotic resistance constitutes one of the most pressing public health concerns. Antimicrobial peptides (AMPs) of multicellular organisms are considered part of a solution to this problem, and AMPs produced by bacteria such as colistin are last-resort drugs. Importantly, AMPs differ from many antibiotics in their pharmacodynamic characteristics. Here we implement these differences within a theoretical framework to predict the evolution of resistance against AMPs and compare it to antibiotic re ...[more]