Ontology highlight
ABSTRACT:
SUBMITTER: Hegyi B
PROVIDER: S-EPMC5879679 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hegyi Bence B Bossuyt Julie J Griffiths Leigh G LG Shimkunas Rafael R Coulibaly Zana Z Jian Zhong Z Grimsrud Kristin N KN Sondergaard Claus S CS Ginsburg Kenneth S KS Chiamvimonvat Nipavan N Belardinelli Luiz L Varró András A Papp Julius G JG Pollesello Piero P Levijoki Jouko J Izu Leighton T LT Boyd W Douglas WD Bányász Tamás T Bers Donald M DM Chen-Izu Ye Y
Proceedings of the National Academy of Sciences of the United States of America 20180312 13
Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in ventricular myocytes from the infarct border and remote zones in a porcine model of post-MI ...[more]