Ontology highlight
ABSTRACT:
SUBMITTER: Pitha I
PROVIDER: S-EPMC5879766 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Pitha Ian I Kimball Elizabeth C EC Oglesby Ericka N EN Pease Mary Ellen ME Fu Jie J Schaub Julie J Kim Yoo-Chun YC Hu Qi Q Hanes Justin J Quigley Harry A HA
Translational vision science & technology 20180328 2
<h4>Purpose</h4>To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma.<h4>Methods</h4>We injected either DPP or control microparticles intravitreally in rats. Two days later, unilateral ocular hypertension was induced by translimbal, diode laser treatment by a surgeon masked to treatment group. IOP and clinical exams were performed until sacrifice 6 weeks after lase ...[more]