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Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast.

ABSTRACT: Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevalence of abnormal hemoglobin among patients attending dispensaries for mild malaria is thus unknown. A retrospective study was conducted to update data on the prevalence of S and C hemoglobin among patients attending dispensaries with mild malaria. Enrolment of patients was conducted during in vivo malaria treatment efficacy survey following the 42 days WHO protocol. A group of non-infected pregnant women and a group of patients with fever different from malaria, were also recruited in the same dispensaries.794 blood samples were included. S and C genotypes were found in all the regions of Ivory Coast with the highest prevalence in the Northern region (S and C genotypes, 27%). In non-infected patients, prevalence of mutations was higher than in malaria patients.A high proportion of patients with mild malaria carried genetic hemoglobin disorder. This population of high risk must be better investigated to control treatment efficacy and to manage complications.

SUBMITTER: Tossea SK

PROVIDER: S-EPMC5880027 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast.

Tossea Stephane Koui SK Adji Eric Gbessi EG Coulibaly Baba B Ako Berenger Ako BA Coulibaly David Ngolo DN Joly Philippe P Assi Serge-Brice SB Toure Andre A Jambou Ronan R

BMC research notes 20180402 1

<h4>Objectives</h4>Sickle cell anemia is due to a mutations on the betaglobin gene, inducing abnormal hemoglobin. In West Africa the main mutations lead to S or C types of hemoglobin. Patients with homozygote mutations seem protected against severe malaria, but not against mild disease. The prevalence of abnormal hemoglobin among patients attending dispensaries for mild malaria is thus unknown. A retrospective study was conducted to update data on the prevalence of S and C hemoglobin among patie ...[more]

PMID: 29609623

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Dataset Information

Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast.

Publications

Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast.

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