Ontology highlight
ABSTRACT:
SUBMITTER: Ye J
PROVIDER: S-EPMC5880207 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Ye Jian J Qiu Ju J Bostick John W JW Ueda Aki A Schjerven Hilde H Li Shiyang S Jobin Christian C Chen Zong-Ming E ZE Zhou Liang L
Cell reports 20171101 8
The local environment may affect the development and function of tissue-resident T regulatory cells (Tregs), which are crucial for controlling inflammation. Although the aryl hydrocarbon receptor (Ahr), an environmental sensor, is expressed by Tregs, its role in Treg cell development and/or function remains elusive. Here, we generated mouse genetic models to ablate or activate Ahr expression specifically in Tregs. We showed that Ahr was expressed more abundantly by peripherally induced Tregs (pT ...[more]