Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC5880308 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhao Xiaofeng X Liao Yuan Y Morgan Shannon S Mathur Ramkumar R Feustel Paul P Mazurkiewicz Joseph J Qian Jiang J Chang Julia J Mathern Gary W GW Adamo Matthew A MA Ritaccio Anthony L AL Gruenthal Michael M Zhu Xinjun X Huang Yunfei Y
Cell reports 20180201 8
Microglia are well known to play a critical role in maintaining brain homeostasis. However, their role in epileptogenesis has yet to be determined. Here, we demonstrate that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proliferation, and robust phagocytosis activity, but without a significant induction of pro-inflammatory cytokines. We further provide evidence that these noninflammatory changes in microglia disrupt homeo ...[more]