Ontology highlight
ABSTRACT:
SUBMITTER: Croft CL
PROVIDER: S-EPMC5880389 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Croft Cara L CL Moore Brenda D BD Ran Yong Y Chakrabarty Paramita P Levites Yona Y Golde Todd E TE Giasson Benoit I BI
PloS one 20180402 4
Tauopathies including Alzheimer's disease and Progressive Supranuclear Palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. The tau pathology burden correlates with neurodegeneration and dementia observed in these diseases. The microtubule binding domain of tau is essential for its physiological functions in promoting neuronal cytoskeletal stability, however it is also requir ...[more]