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Network Reconstruction From High-Dimensional Ordinary Differential Equations.

ABSTRACT: We consider the task of learning a dynamical system from high-dimensional time-course data. For instance, we might wish to estimate a gene regulatory network from gene expression data measured at discrete time points. We model the dynamical system nonparametrically as a system of additive ordinary differential equations. Most existing methods for parameter estimation in ordinary differential equations estimate the derivatives from noisy observations. This is known to be challenging and inefficient. We propose a novel approach that does not involve derivative estimation. We show that the proposed method can consistently recover the true network structure even in high dimensions, and we demonstrate empirical improvement over competing approaches. Supplementary materials for this article are available online.

SUBMITTER: Chen S

PROVIDER: S-EPMC5880569 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Network Reconstruction From High-Dimensional Ordinary Differential Equations.

Chen Shizhe S Shojaie Ali A Witten Daniela M DM

Journal of the American Statistical Association 20170807 520

We consider the task of learning a dynamical system from high-dimensional time-course data. For instance, we might wish to estimate a gene regulatory network from gene expression data measured at discrete time points. We model the dynamical system nonparametrically as a system of additive ordinary differential equations. Most existing methods for parameter estimation in ordinary differential equations estimate the derivatives from noisy observations. This is known to be challenging and inefficie ...[more]

PMID: 29618851

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