Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.
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ABSTRACT:
SUBMITTER: Bharti SK
PROVIDER: S-EPMC5880607 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.
Bharti Santosh K SK Mironchik Yelena Y Wildes Flonne F Penet Marie-France MF Goggins Eibhlin E Krishnamachary Balaji B Bhujwalla Zaver M ZM
Oncotarget 20180224 20
Hypoxia is frequently encountered in tumors and results in the stabilization of hypoxia inducible factors (HIFs). These factors transcriptionally activate genes that allow cells to adapt to hypoxia. In cancers, hypoxia and HIFs have been associated with increased invasion, metastasis, and resistance to chemo and radiation therapy. Here we have characterized the metabolic consequences of silencing HIF-1α and HIF-2α singly or combined in MDA-MB-231 triple negative human breast cancer xenografts, u ...[more]
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