Ontology highlight
ABSTRACT:
SUBMITTER: Gohar F
PROVIDER: S-EPMC5880729 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
The Journal of rheumatology 20180115 4
<h4>Objective</h4>Around one-third of patients with juvenile idiopathic arthritis (JIA) fail to respond to first-line methotrexate (MTX) or anti-tumor necrosis factor (TNF) therapy, with even fewer achieving ≥ American College of Rheumatology Pediatric 70% criteria for response (ACRpedi70), though individual responses cannot yet be accurately predicted. Because change in serum S100-protein myeloid-related protein complex 8/14 (MRP8/14) is associated with therapeutic response, we tested granulocy ...[more]