Ontology highlight
ABSTRACT:
SUBMITTER: Dejea CM
PROVIDER: S-EPMC5881113 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Dejea Christine M CM Fathi Payam P Craig John M JM Boleij Annemarie A Taddese Rahwa R Geis Abby L AL Wu Xinqun X DeStefano Shields Christina E CE Hechenbleikner Elizabeth M EM Huso David L DL Anders Robert A RA Giardiello Francis M FM Wick Elizabeth C EC Wang Hao H Wu Shaoguang S Pardoll Drew M DM Housseau Franck F Sears Cynthia L CL
Science (New York, N.Y.) 20180201 6375
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of <i>Escherichia coli</i> and <i>Bacteroides fragilis</i> Genes fo ...[more]