Ontology highlight
ABSTRACT:
SUBMITTER: Trejo P
PROVIDER: S-EPMC5881132 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Trejo Pamela P Rauch Frank F Ward Leanne L
Journal of musculoskeletal & neuronal interactions 20180301 1
Children with osteogenesis imperfecta (OI) type VI often have high fracture rates despite the current standard treatment with bisphosphonates. Subcutaneous injections of denosumab have been proposed as an alternative treatment approach, but safety data on denosumab in children are limited. Here we describe fluctuations in bone and mineral metabolism during denosumab treatment in four children with OI type VI who started denosumab (basic protocol: 1 mg per kg body mass every 3 months) between 1.9 ...[more]