Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC5881458 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Zhang Yang Y Tech Laura L George Laura A LA Acs Andreas A Durrett Russell E RE Hess Henry H Walker Lucy S K LSK Tarlinton David M DM Fletcher Anne L AL Hauser Anja Erika AE Toellner Kai-Michael KM
The Journal of experimental medicine 20180316 4
Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The regulation of cellular output from the GC is not well understood. Here, we show that from the earliest stages of the GC response, plasmablasts emerge at the GC-T zone interface (GTI). We define two main factors that regulate this process: Tfh-derived IL-21, which supports production of plasmablasts from the GC, and TNFSF13 (APRIL), which is produced by a population of podoplanin<sup>+</sup> CD157<sup>high</sup> f ...[more]