Ontology highlight
ABSTRACT:
SUBMITTER: Merlini L
PROVIDER: S-EPMC5881505 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Merlini Laura L Khalili Bita B Dudin Omaya O Michon Laetitia L Vincenzetti Vincent V Martin Sophie G SG
The Journal of cell biology 20180216 4
In the fission yeast <i>Schizosaccharomyces pombe</i>, pheromone signaling engages a signaling pathway composed of a G protein-coupled receptor, Ras, and a mitogen-activated protein kinase (MAPK) cascade that triggers sexual differentiation and gamete fusion. Cell-cell fusion requires local cell wall digestion, which relies on an initially dynamic actin fusion focus that becomes stabilized upon local enrichment of the signaling cascade on the structure. We constructed a live-reporter of active R ...[more]